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CK-MM gene polymorphism does not influence the blood CK activity levels after exhaustive eccentric exercise

机译:CK-mm基因多态性对力竭性离心运动后血液CK活性水平无影响

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摘要

Gene variants, such as creatine kinase (CK) polymorphisms,\udhave been suggested to explain the\udinter-individual blood CK response to eccentric\udexercise. However, since this association is still\uddoubtful, the purpose of this study was to analyse\udthe relationship between the magnitudes of\udthe CK response to exercise with the occurrence\udof muscle CK-MM NcoI polymorphism in young\udhealthy subjects. Blood CK activity was assessed\udin 70 subjects immediately before and 3, 24, 48,72, 96, 120, 168 h after strenuous eccentric exercise.\udBased on the amount of CK release by each\udsubject, the sample was distributed in quartiles\udand the genotype and allele frequency distribution\udwas compared among quartiles. Despite\udthe inter-individual variability of CK response\udobserved between subjects, there were no diff erences\udin genotype and allele frequencies among\udquartiles. The results allowed us to conclude that\udCK response after exhaustive eccentric exercise is\udnot associated with CK-MM Ncol polymorphism.
机译:有人建议使用基因变异(例如肌酸激酶(CK)多态性)来解释\ udud个人血液CK对偏心\ udexercise的反应。但是,由于这种关联仍是\怀疑的,因此本研究的目的是分析\对年轻\ udhealth受试者的运动对CK反应幅度与肌肉CK-MM NcoI多态性的发生之间的关系。在剧烈的离心运动之前和之后的30、24、48、72、96、120、168小时和70个受试者中评估其CK血液活性。\ ud基于每个受试者的CK释放量,将样本分布在四分位数中\ ud,比较了四分位数之间的基因型和等位基因频率分布。尽管受试者之间CK反应的个体间差异存在差异,但在\四分位数之间没有差异\ udin基因型和等位基因频率。结果使我们得出结论,穷举运动后的udCK反应与CK-MM Ncol多态性无关。

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